Several studies have shown that supplementation with the B vitamin B6 (pyridoxine) alone or with combination with magnesium can lead to significant improvements in alertness, communication and social skills. There even was a change in IQ scores with those who took vitamin B6
Most of the studies used higher than usual doses of both B6 and magnesium The doses of Vitamin B6 were 30 mg /kg of body weight whereas the magnesium dose was 6-15 mg /kg of body weight up to 1000 mg /day
This was an excellent study but there is a limit to the amount of vitamin B6 as greater than 400 mg can be toxic to the body. I feel we need to study the amount of minerals that are deficient in certain diseases as cardiovascular diseases, diabetes and autism.