AUGUSAT 5, 2025 METHYTLATED VITAMINS

For years I have been discussing methylation. I remember hearing a lecture about methylation and I started reading I went to a website ww.mthfr.net If you’ve ever taken a B complex and still felt fatigued, or been told you have elevated homocysteine levels, it may be time to look into methylated B vitamins.

Methylation is a biochemical process that occurs billions of times a day in your body. It’s how your cells perform essential tasks like:

• Producing neurotransmitters for mood and focus

• Regulating gene expression

• Processing toxins in the liver

• Creating energy (ATP) at the cellular level

• Converting homocysteine into methionine for heart health
  

For methylation to occur efficiently, your body requires specific methyl donors, primarily from B vitamins — including methylated folate (5-MTHF) and methylcobalamin (B12) If you feel tired even after a good night’s sleep, a deficiency or impaired usage of B vitamins may be contributing. Methylated B12 (methylcobalamin) and methylated folate (5-MTHF) are essential for converting food into energy and fueling your cells.They also help maintain the health of your nervous system and support the production of red blood cells — both key components in sustained energy.Many patients feel a significant difference in their focus and vitality when they switch to a high-quality formula with methylated B vitamins.

Methylati9on is imnportant for cardiovascular support We do know that homocysteine is a risk factor for premature vascular damage 40 % of people cannot bring down homocysteine with a regular B12 and folate This 40 % of indi8viduals have a MTHFR gene whether MTHFR 677 or MTHFR 1298 Methylated forms of B6, B12, and folate are critical for converting homocysteine into methionine, an amino acid needed for healthy cardiovascular function. Without this conversion, homocysteine builds up and damages blood vessels over time We also need methylation for detoxification Methylation also supports phase II liver detoxification, where your body neutralizes toxins so they can be safely eliminated. This includes everything from heavy metals and hormones to environmental chemicals. There are many individuals who cannot detox mycotoxins, metals, and other toxins fro their bodies. This is because they have a MTHFR gene

Ask your doctor to check for MTHFR genes

Until tomorrow…

AUGUST 4, 2025 AKKERMANSIA

Akkermansia muciniphila (sometimes misspelled “Akkamensia”) is a beneficial gut bacterium that has drawn increasing scientific interest for its role in immune regulation, gut health, and metabolic balance. More recently, it has been linked to cancer research, especially in relation to the immune system’s response to cancer therapies.

As far as the gut microbiome and tumor progression -

Akkermansia helps maintain the gut barrier, preventing systemic inflammation, which can promote tumor growth It may modulate inflammatory cytokines and impact T-cell infiltration into tumors, enhancing the body’s natural anti-tumor response.

For cxolon and gastric cancers it has been found that Because A. muciniphila is a mucin-degrading bacterium, it interacts directly with the intestinal lining. While beneficial in healthy individuals, in some cases (e.g., with a compromised mucosal barrier), the role of Akkermansia is still under investigation. Some studies suggest it may protect against colon cancer by strengthening the gut lining and reducing chronic inflammation.

In summary Akkermnansia has three importantr points

1. Promising as a cancer immunotherapy enhancer

2. Supports gut and immune health, reducing inflammation

3 More research is needed for direct anti-cancer applications, but early findings are very encouraging

Until tomorrow

JULY 30, 2025 PEPTIDES

What are ppetides ? Peptides are short protein chains of about 2-100 amino acids. Your body makes peptides that serve important functions in some of your body's most necessary processes, including how you digest and use energy from the food you eat, how hungry you feel, how your hormones work, and cell movement

Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones, growth factors, neurotransmitters, ion channel ligands, and anti-infectives; peptide therapeutics mimic such functions.

At Fratellone Medical we consider new therapies all the time with our team researching , discussing and meeting about different treatment strategies

Individuals who should exercise caution or avoid peptide use include pregnant or breastfeeding individuals, those with autoimmune conditions, those with severe allergies, and individuals with underlying organ issues

While many peptides are no longer FDA-approved for compounding, some are still available through: FDA-approved pharmaceutical versions (e.g., Tesamorelin for HIV-related fat loss

We as practitioners are being well informed about peptides through various conferences. We have been on a peptide journey I am proud to say that associates/colleague Dr Hannibal Miles and myself are using peptides for a variety of health conditions. in our patient population

Have a consult with Dr Hannibal Miles for peptides Call 212 421 3202

Until tomorrow…

JULY 29, 2025 SUMMER FRUIT

There are many summer fruits to eat which are super foods. One is Watermelon You don’t have to ditch the juicy red part of the watermelon – but don’t sleep on the seeds or rind. “Both can support circulation and hydration,” Dr. Wu notes. “And the rind has lots of fiber and amino acids.” Simply roast the seeds for a crunchy, protein-packed snack, or toss the rind into a stir-fry. It is high is sugar but a few pieces with your berries cannot hurt.

There are tart cherries. Whether you’re sore from a workout or just want a good night’s sleep, these might be for you. “Tart cherries, or tart cherry juice, are loaded with antioxidants. They’re great for reducing inflammation or speeding up recovery,” Dr. Wu notes. Bonus: they naturally contain melatonin, which may help you sleep better, too.

Have you heard about the benefits of papaya “Papaya is full of potassium and has enzymes which help with digestion and preventing bloating, while guava is absolutely packed with vitamin C. It has even more than an orange,” says Dr. Wu. Both are refreshing and flavorful, and make a perfect addition to your next smoothie or salsa.

So the next time you’re at the farmer’s market or planning your next backyard barbecue, throw a few of these unexpected superfoods into the mix. You’ll feel better, eat better — and maybe even impress your guests while you’re at it.

Thank you Ulysses Wu, MD

Until tomorrow…

JULY 28, 2025 APRICOTS

pricots might just be one of the most powerful fruits you’re not eating. While their popularity in the U.S. has steadily dropped since the 1990s, apricots are loaded with nutrients that can support heart health, brain function, digestion, and much more.

They also belong to the Rosaceae family, which includes many other edible fruits and nuts, such as cherries, peaches, plums, and almonds Thet are certainly different than their cousin fruits- plum , peaches and cherries. I would eat a plum or peach- rather than an apricot. It also provides 18% of the recommended daily intake of vitamins A and C (based on a 2,000 calorie per day diet), and is a good source of several B vitamins. When it comes to minerals, apricots are not slouches. Theyʼre good sources of potassium, copper, iron, manganese, and magnesium. Apricots contain a lot of beta carotene which gives them its orange color Apricots also deliver lutein and zeaxanthin, antioxidant carotenoids known to benefit eye health.

There are good study on apricots and cancer. A 2005 study found that the pulp of a Japanese apricot variety was able to suppress the growth of several types of cancer in vitro, including that of the stomach, blood, and pancreas. apricot-related health benefits seen in studies, including protecting the brain and heart, fighting against oxidation, boosting the immune system, and lowering high cholesterol.

So there is not reason not to try to eat an apricot. After researching apricots I will add them to my summer fruit list.

Until tomorrow…

JULY 21, 2025 B 17

B17 Amygdalin 500mg Capsules, a premium dietary supplement that provides your body and immune system with the essential benefits of Vitamin B-17.

Naturally occurring in over 1,200 food sources including apricot, plum, cherry, orange, nectarine, apple and peach seeds as well as a variety of raw nuts, Vitamin B-17 provides power immunity-boosting properties It is alo called Laetrile Laetrile was used as a cancer treatment in the 1970’s Laetrile is promoted as an alternative cancer treatment. There is not enough reliable evidence that it works.

Summary Laetrile is a man-made form of amygdalin, a plant substance found in some nuts, plants and seeds of fruit.Claims that laetrile or amygdalin can treat cancer are not backed up by research.It contains cyanide, a poison and can cause serious side effects Some people call laetrile vitamin B17, although it isn’t a vitamin.  Today , Laetrile is not used r as popular as it was. I our practice we utilize a chemosensitivity/herb/supplement sensitivity test from Greece called RGCC his lab tests for B17 against certain cancers. People who use laetrile believe it might :improve their health, energy levels and well being detoxify and cleanse the body help them to live longer

Until tomorrow

JULY 14, 2025 ASHWAGANDHA

In ancient Ayurvedic medicine, ashwagandha is known as the King of Herbs.

Today, it’s one of the most popular adaptogens in the wellness world — and for good reason. It’s been celebrated for its ability to ease stress, improve sleep, boost energy, support brain health, and even help the body fight cancer Ashwagandha is an herb made from the Withania somnifera (meaning “sleep-inducing”) plant, with thousands of years of use in Ayurveda. It’s in the Solanaceae or nightshade family, along with tomatoes, potatoes, and eggplant (and, in the spirit of full disclosure, the extremely toxic belladonna). It’s also known as Indian ginseng or winter cherry Ashwagandha belongs to a category of substances known as adaptogens. There are many adaptogenic herbs. Even Reishi mushroom is considered a secondary adaptogen

A 2019 study randomized 60 “stressed adults” into three groups. They received either 250 or 600 mg of ashwagandha per day for 8 weeks, or a placebo. Compared to the control group, those given the herb reported significant reductions in how stressed they felt. And those perceptions were supported by reductions in their serum levels of the stress hormone cortisol. Both ashwagandha groups also showed significant improvement in sleep quality compared to the placebo group

A more recent study showed benefit. A 2022 meta-analysis of 12 studies that included over 1,000 adults found that ashwagandha seems to lower anxiety and stress when compared to a placebo. Taking up to 12,000 mg (4 teaspoons) per day seemed to be the sweet spot to treat anxiety, while a much smaller dose of 300–600 mg per day was found to help with stress.

This is a herb that every person should take. Those with thyroid disease should consult their health care practitioner first

Until tomorrow…

JULY 8, 2025 VITAMIN C

A healthy amount of vitamins is one of the keys to staying happy and healthy. Humans need certain amounts of each vitamin and each vitamin has its own job to do in your body There are some individuals who take no vitamins and there are some who take too many

You should see a physician that measures levels of vitamins. You should discuss the importance of vitamin D and a methylated B vitamin in your regimen One vitamin everyone should take is Vitamin C

This potent antioxidant contributes to normal collagen formation, bone function, skin, cartilage, blood vessels, teeth, and gum health. Supports the immune and nervous systems and aids metabolism. Unlike most pills and powders, our Liposomal Vitamin C doesn’t cause stomach upset and mixes easily with any drink.

I take Liposomal Vitamin C everyday

Until tomorrow…