AUGUSAT 5, 2025 METHYTLATED VITAMINS
For years I have been discussing methylation. I remember hearing a lecture about methylation and I started reading I went to a website ww.mthfr.net If you’ve ever taken a B complex and still felt fatigued, or been told you have elevated homocysteine levels, it may be time to look into methylated B vitamins.
Methylation is a biochemical process that occurs billions of times a day in your body. It’s how your cells perform essential tasks like:
Producing neurotransmitters for mood and focus
Regulating gene expression
Processing toxins in the liver
Creating energy (ATP) at the cellular level
Converting homocysteine into methionine for heart health
For methylation to occur efficiently, your body requires specific methyl donors, primarily from B vitamins — including methylated folate (5-MTHF) and methylcobalamin (B12) If you feel tired even after a good night’s sleep, a deficiency or impaired usage of B vitamins may be contributing. Methylated B12 (methylcobalamin) and methylated folate (5-MTHF) are essential for converting food into energy and fueling your cells.They also help maintain the health of your nervous system and support the production of red blood cells — both key components in sustained energy.Many patients feel a significant difference in their focus and vitality when they switch to a high-quality formula with methylated B vitamins.
Methylati9on is imnportant for cardiovascular support We do know that homocysteine is a risk factor for premature vascular damage 40 % of people cannot bring down homocysteine with a regular B12 and folate This 40 % of indi8viduals have a MTHFR gene whether MTHFR 677 or MTHFR 1298 Methylated forms of B6, B12, and folate are critical for converting homocysteine into methionine, an amino acid needed for healthy cardiovascular function. Without this conversion, homocysteine builds up and damages blood vessels over time We also need methylation for detoxification Methylation also supports phase II liver detoxification, where your body neutralizes toxins so they can be safely eliminated. This includes everything from heavy metals and hormones to environmental chemicals. There are many individuals who cannot detox mycotoxins, metals, and other toxins fro their bodies. This is because they have a MTHFR gene
Ask your doctor to check for MTHFR genes
Until tomorrow…
AUGUST 4, 2025 AKKERMANSIA
Akkermansia muciniphila (sometimes misspelled “Akkamensia”) is a beneficial gut bacterium that has drawn increasing scientific interest for its role in immune regulation, gut health, and metabolic balance. More recently, it has been linked to cancer research, especially in relation to the immune system’s response to cancer therapies.
As far as the gut microbiome and tumor progression -
Akkermansia helps maintain the gut barrier, preventing systemic inflammation, which can promote tumor growth It may modulate inflammatory cytokines and impact T-cell infiltration into tumors, enhancing the body’s natural anti-tumor response.
For cxolon and gastric cancers it has been found that Because A. muciniphila is a mucin-degrading bacterium, it interacts directly with the intestinal lining. While beneficial in healthy individuals, in some cases (e.g., with a compromised mucosal barrier), the role of Akkermansia is still under investigation. Some studies suggest it may protect against colon cancer by strengthening the gut lining and reducing chronic inflammation.
In summary Akkermnansia has three importantr points
Promising as a cancer immunotherapy enhancer
2. Supports gut and immune health, reducing inflammation
3 More research is needed for direct anti-cancer applications, but early findings are very encouraging
Until tomorrow
JULY 30, 2025 PEPTIDES
What are ppetides ? Peptides are short protein chains of about 2-100 amino acids. Your body makes peptides that serve important functions in some of your body's most necessary processes, including how you digest and use energy from the food you eat, how hungry you feel, how your hormones work, and cell movement
Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones, growth factors, neurotransmitters, ion channel ligands, and anti-infectives; peptide therapeutics mimic such functions.
At Fratellone Medical we consider new therapies all the time with our team researching , discussing and meeting about different treatment strategies
Individuals who should exercise caution or avoid peptide use include pregnant or breastfeeding individuals, those with autoimmune conditions, those with severe allergies, and individuals with underlying organ issues
While many peptides are no longer FDA-approved for compounding, some are still available through: FDA-approved pharmaceutical versions (e.g., Tesamorelin for HIV-related fat loss
We as practitioners are being well informed about peptides through various conferences. We have been on a peptide journey I am proud to say that associates/colleague Dr Hannibal Miles and myself are using peptides for a variety of health conditions. in our patient population
Have a consult with Dr Hannibal Miles for peptides Call 212 421 3202
Until tomorrow…
JULY 29, 2025 SUMMER FRUIT
There are many summer fruits to eat which are super foods. One is Watermelon You don’t have to ditch the juicy red part of the watermelon – but don’t sleep on the seeds or rind. “Both can support circulation and hydration,” Dr. Wu notes. “And the rind has lots of fiber and amino acids.” Simply roast the seeds for a crunchy, protein-packed snack, or toss the rind into a stir-fry. It is high is sugar but a few pieces with your berries cannot hurt.
There are tart cherries. Whether you’re sore from a workout or just want a good night’s sleep, these might be for you. “Tart cherries, or tart cherry juice, are loaded with antioxidants. They’re great for reducing inflammation or speeding up recovery,” Dr. Wu notes. Bonus: they naturally contain melatonin, which may help you sleep better, too.
Have you heard about the benefits of papaya “Papaya is full of potassium and has enzymes which help with digestion and preventing bloating, while guava is absolutely packed with vitamin C. It has even more than an orange,” says Dr. Wu. Both are refreshing and flavorful, and make a perfect addition to your next smoothie or salsa.
So the next time you’re at the farmer’s market or planning your next backyard barbecue, throw a few of these unexpected superfoods into the mix. You’ll feel better, eat better — and maybe even impress your guests while you’re at it.
Thank you Ulysses Wu, MD
Until tomorrow…